Noticia

The Institute of Metabolic and Cardiovascular Diseases (I2MC) is recognized for its translational

research in the field of metabolic (obesity, diabetes, dyslipidemias) and cardiovascular (thrombosis,

atherosclerosis, cardiac and renal failure) diseases. Currently, the I2MC is composed of 11 teams.

Translation to the clinic is greatly facilitated by the location within the Rangueil site of Toulouse

University Hospitals. Notably, clinical departments devoted to nutrition, cardiovascular and renal

diseases, obesity and diabetes are in close vicinity of I2MC.

I2MC offers scientists a diverse set of competence through its 7 core facilities (Lipidomics, Imaging,

Bioinformatics, Functional Biochemistry, Cytometry, Histology, Genomics & Transcriptomics).

The overarching goal of the research in the laboratory of Dr. Martinez (LiMitAging Team) is to

explore the relation between some actors of mitochondrial functions and aging, and is driven by the

hypothesis that enhancing mitochondrial health and mitochondrial quality-control mechanisms will

promote healthy aging. In particular, the team's research in the field of lipoprotein and mitochondria

led to identify original actors associated to lipid and mitochondrial energy metabolism.

https://pubmed.ncbi.nlm.nih.gov/?term=martinez+LO&sort=date

The project will aim to explore the regulation and function of a novel regulator of mitochondrial

oxidative phosphorylation (OXPHOS) at the cell, organ, and whole-organism levels and in different

pathophysiological conditions. Pharmacological approaches to target mitochondrial energy

metabolism will be also explored.

We are seeking talented, conscientious, motivated and enthusiastic postdoctoral scientists

interested in the field of mitochondrial biology to join our team. Dr. Martinez is committed to

provide the training and resources needed for the lab members to achieve their goals at any point in

their career path in an inclusive and inspirational environment.

Desired qualification:

• Molecular, biochemical and cellular imaging methods to study mitochondria

• Knowledge in mitochondrial energy metabolism

• Experience with any specific disease or organ dysfunction in mice (liver, muscle, adipose

tissue, vascular endothelium)

• RNA-Seq and OMICs data analyses

Eligibility criteria:

• PhD in biology

• All nationalities

Apply now to Laurent.martinez@inserm.fr with letter of motivation, CV and email of 2-3 references.