El próximo lunes día 25 de noviembre a las 12h en el salón de grados del LAIB, tendrá lugar el siguiente seminario externo IMIB:
Autophagy in neurons: from development to aging
Impartido por la Dra. Patricia Boya
Investigadora Científica CSIC
Grupo: Funciones de la autofagia en la fisiopatología de los organismos
Centro de Investigaciones Biológicas CIB-CSIC. Madrid
Autophagy is an evolutionarily conserved process that occurs at basal conditions and promotes cellular homeostasis through the recycling of cellular components and supplying energy during periods of metabolic stress. In response to many types of cellular stress, autophagy plays a cytoprotective role. We want to understand why the process of autophagy is essential to maintain cellular homeostasis and how deregulations in this mechanism can influence several pathological situations. In particular we have demonstrated that autophagy is an early cytoprotective response during several neurodegenerative conditions. Axonal damage in autophagy-deficient animals increases cell death and conversely, pharmacological upregulation of this process increases neuronal survival. In addition we are interested in the role of autophagy during the aging process in the nervous system and have recently found a decrease in the activity of macroautophagy that seems to be partially compensated by un upregulation of other lysosomal pathways as chaperone mediated autophagy. In this seminar I will present the latest results from our lab on the role of autophagy in neurons, from development to aging.
Para más información: https://autofagia.org/project/pat-boya/
