Noticia

Current projects include:

• Discovery of mechanisms of resistance to breast cancer therapies (i.e., estrogen receptor antagonists, CDK4/6 inhibitors, HER2 inhibitors, PI3K/AKT inhibitors)
• Genomic profiling of drug-resistant breast cancers
• Identifying rational combinations to overcome resistance to targeted therapies 

We incorporate molecular profiling (next-gen DNA/RNA sequencing) of patient tumors, CRISPR, forward genetics, and gain-of-function ORF screens, and mechanistic studies using breast cancer cell lines, cell line-derived xenografts, and patient-derived organoids and xenografts, with the goal of using insights from the laboratory to guide clinical trials. 

Relevant recent publications that apply to these topics include:

• Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer. Nat Commun. 2020 Oct 30;11(1):5488.
• Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers. Cancer Cell. 2020 Feb 10;37(2):183-199.e5.
• Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer. Nat Commun. 2019 Mar 26;10(1):1373.
• ER+ Breast Cancers Resistant to Prolonged Neoadjuvant Letrozole Exhibit an E2F4 Transcriptional Program Sensitive to CDK4/6 Inhibitors. Clin Cancer Res. 2018 Jun 1;24(11):2517-2529.
• Genomic profiling of ER+ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance. Sci Transl Med. 2017 Aug 9;9(402):eaai7993.
• An Acquired HER2(T798I) Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer. Cancer Discov. 2017 Jun;7(6):575-585. Applicants with a recent Ph.D., M.D., or M.D./Ph.D. and a strong background in molecular & cell biology and genomics with an interest in translational research are encouraged to apply. A track record of productivity and publications in well-established journals is essential. 

Information on our postdoctoral training program and benefits can be found in our Postdoc Handbook or at http://www.utsouthwestern.edu/postdocs.

Interested individuals should send a CV, statement of interests, and a list of three references to: Carlos L. Arteaga, MD UT Southwestern Medical Center 5323 Harry Hines Blvd. Dallas, TX 75390-8807 

Carlos.Arteaga@utsouthwestern.edu

https://profiles.utsouthwestern.edu/profile/146478/carlos-arteaga.html 

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